2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-123349
    5α-Hydroxy-6-keto cholesterol
    		99.9%
    5α-Hydroxy-6-keto cholesterol is major metabolite of β-epoxide (5α,6β-epoxycholesterol) during direct exposure of intact cultured human bronchial epithelial cells (16-HBE) to ozone. 5α-Hydroxy-6-keto cholesterol inhibits cholesterol synthesis with an IC50 of 350 nM.
    5α-Hydroxy-6-keto cholesterol
  • HY-103005
    Ramelteon metabolite M-II
    		98.84%
    Ramelteon metabolite M-II is the major metabolite of Ramelteon, with IC50s of 208 pM, 1470 pM for human melatonin receptors (MT1 or MT2). Ramelteon is a selective melatonin agonist.
    Ramelteon metabolite M-II
  • HY-13318A
    Oseltamivir acid hydrochloride
    		99.41%
    Oseltamivir acid hydrochloride is an active metabolite of the antiviral agent Oseltamivir (HY-13317) ethylester. Oseltamivir acid hydrochloride belongs to baseline toxicants in toxicity ratio analysis.
    Oseltamivir acid hydrochloride
  • HY-121652
    Mefox
    		99.89%
    Mefox is a degradation product of folic acid (HY-16637).
    Mefox
  • HY-125947
    4-Epioxytetracycline
    		99.16%
    4-Epioxytetracycline, the degradation product of Oxytetracycline (OTC), can be found in swine manure compost and wastewater.
    4-Epioxytetracycline
  • HY-130239A
    (±)14-HDHA
    		99.9%
    (±)14-HDHA is the isomer of 14(S)-HDHA (HY-130239). 14(S)-HDHA is an oxygenation product of Docosahexaenoic acid (DHA). 14(S)-HDHA is a marker reflecting activation of a Docosahexaenoic acid carbon 14-lipoxygenation pathway.
    (±)14-HDHA
  • HY-W019773
    Albendazole sulfone
    		98.16%
    Albendazole sulfone is a metabolite of Albendazole, and exhibits anti-parasite effect against Echinococcus multilocularis Metacestodes.
    Albendazole sulfone
  • HY-W013266
    N4-Acetylsulfamethoxazole
    		99.72%
    N4-Acetylsulfamethoxazole (Acetylsulfamethoxazole) is the N4-acetylated metabolite of Sulfamethoxazole (HY-B0322).
    N4-Acetylsulfamethoxazole
  • HY-117580
    16α-Hydroxyprednisolone
    		99.78%
    16α-Hydroxyprednisolone (OH-PRED) is a stereoselective metabolite of the 22(R) epimer of the glucocorticoid Budesonide (HY-13580). 16α-Hydroxyprednisolone formation is catalyzed by isoenzymes within the cytochrome P450 3A (CYP3A) subfamily. 16α-Hydroxyprednisolone formation can be inhibited by antibodies targeting the CYP3A subfamily.
    16α-Hydroxyprednisolone
  • HY-118816
    11β-Prostaglandin F2α
    11β-Prostaglandin F2α ethanolamide (11β-PGF2α-EA) is the theoretical hepatic metabolite of PGD2-EA, produced during COX-2 metabolism of the endogenous cannabinoid AEA which is found in brain, liver, and other mammalian tissues.1 AEA can be used directly by COX-2 and specific PG synthase to produce ethanolamide congeners of the classical PGs. PGD2-EA is formed in activated RAW 264.7 cells treated with AEA.
    11β-Prostaglandin F2α
  • HY-N10508
    Calcitroic acid
    Calcitroic acid is a vitamin D receptor (VDR) agonist that can activate VDR-mediated transcription. Calcitroic acid is the main metabolite of 1,25-dihydroxyvitamin D3, with the highest concentrations found in the liver and mucosa of mice, and it has metabolic stability and very low toxicity.
    Calcitroic acid
  • HY-N11224
    Pregnanetriol
    		99.8%
    Pregnanetriol is a metabolite of 17α-Hydroxyprogesterone (HY-B0891). 17α-Hydroxyprogesterone is an endogenous progesterone.
    Pregnanetriol
  • HY-B2121
    6-Methoxy-2-naphthoic acid
    		99.73%
    6-Methoxy-2-naphthoic acid (6-MNA) is the active metabolite of Nabumetone (HY-B0559). 6-Methoxy-2-naphthoic acid is also an inhibitor of COX-1 and COX-2. 6-Methoxy-2-naphthoic acid can inhibit the synthesis of gastric mucosal prostaglandin E2. 6-Methoxy-2-naphthoic acid can be used in the research of inflammation and pain-related diseases. In addition, 6-Methoxy-2-naphthoic acid is an impurity in Naproxen (HY-15030) and can also be used in the synthesis of other active compounds.
    6-Methoxy-2-naphthoic acid
  • HY-W588194
    Cotinine N-β-D-Glucuronide
    Cotinine N-β-D-Glucuronide is a glucuronide conjugate of the tobacco metabolite Cotinine (HY-B1178). Cotinine N-β-D-Glucuronide is promising for research of tobacco carcinogen metabolism and cognitive function.
    Cotinine N-β-D-Glucuronide
  • HY-125587
    25-Desacetyl rifampicin
    25-Desacetyl rifampicin (Desacetylrifampicin) is a metabolite of Rifampin (HY-B0272) via β-esterase. Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens.
    25-Desacetyl rifampicin
  • HY-118025
    (±)-2-Oxo clopidogrel
    		99.67%
    (±)-2-Oxo clopidogrel is a metabolite of the antiplatelet agent Clopidogrel (HY-15283).
    (±)-2-Oxo clopidogrel
  • HY-B1259
    6-Acetamidohexanoic acid
    		98.0%
    6-Acetamidohexanoic acid (Acexamic acid; 6-Acetamidocaproic acid) is a metabolite of Hexamethylene bisacetamide (HMBA) (HY-124284) with anti-pulmonary fibrosis activity. 6-Acetamidohexanoic acid does not induce differentiation of human promyelocytic leukemia cells, but is taken up by such cells. 6-Acetamidohexanoic acid serves as a carboxylic acid substrate component for constructing carboxylesterase-responsive near-infrared phototheranostic probes. 6-Acetamidohexanoic acid is applicable to research related to pulmonary fibrosis, refractory hypoxemia and cervical cancer.
    6-Acetamidohexanoic acid
  • HY-133010
    Tamoxifen N-oxide
    		98.00%
    Tamoxifen N-oxide is a Tamoxifen (HY-13757A) metabolite.
    Tamoxifen N-oxide
  • HY-135604
    Dibutyl phosphate
    		98.0%
    Dibutyl phosphate (DBUP) is a urinary metabolite of organophosphate esters (OPEs). Dibutyl phosphate is positively correlated with an increased risk of sarcopenia.
    Dibutyl phosphate
  • HY-13056
    SMND-309
    SMND-309 is a metabolite of salvianolic acid B, and exhibits neuroprotective effects in cultured neurons and in permanent middle cerebral artery occlusion rats.
    SMND-309
Cat. No. Product Name / Synonyms Application Reactivity